Complement activation during cardiopulmonary bypass
نویسندگان
چکیده
منابع مشابه
The Effect of Methylprednisolone on Complement Activation during Cardiopulmonary Bypass
____________ _ A prospective randomized trial in 80 patients having heart surgery was undertaken to test the hypothesis that steroids (ST) (methylprednisolone, 30 mg/kg) would prevent or reduce complement activation during cardiopulmonary bypass (CPB) with membrane (MEM) or bubble (BUB) oxygenators. Group I patients had MEM and ST; Group II, MEM without ST; Group III, BUB and ST; Group IV, BUB ...
متن کاملComplement activation during cardiopulmonary bypass by heparin-protamine interaction.
Circulating concentrations of split products of the third complement factor (C3c and C3d) were measured in five patients before, during and after cardiopulmonary bypass. In all patients, C3d concentrations increased significantly in samples obtained after the administration of protamine sulphate. Similarly, circulating C3c was seen only in those samples obtained immediately after protamine admi...
متن کاملAPT070 inhibits complement activation during in vitro cardiopulmonary bypass.
BACKGROUND The proteins of the complement cascade play an important role in inflammation and the immune response. They have been shown to be activated during cardiopulmonary bypass (CPB), and may be responsible for the inflammatory response to CPB. We looked at the effect of APT070, an anti-complement agent, on human blood during in vitro CPB. MATERIALS AND METHODS Four hundred millilitres of...
متن کاملComplement Activation Induced by Different Tubings Used for Cardiopulmonary Bypass
____________ _ Complement activation induced by latex, polyvinylchloride, and silicone tubings for extracorporeal circulation was studied in 2 in vitro situations: Fresh whole human blood mixed with priming solution was circulated through 1 00 em tubing lengths for 1 hour, and small tubing pieces were incubated in fresh human serum for 7 hours. Activation of C3 and of the terminal pathway (C5-C...
متن کاملComplement activation during cardiopulmonary bypass: quantitative study of effects of methylprednisolone and pulsatile flow.
Forty four patients undergoing open heart surgery were divided into three groups. Group 1 (17 patients) underwent routine anaesthesia and surgery; group 2 (17 patients) received two doses of methylprednisolone (30 mg/kg), one during induction of anaesthesia and the other immediately before induction of cardiopulmonary bypass; and group 3 (10 patients) received pulsatile flow while undergoing pu...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 1986
ISSN: 0022-5223
DOI: 10.1016/s0022-5223(19)36089-1